V-165
Chemical Name: 5-(4-Nitrophenyl)-4,6-dihydroxy-2,8-disulfanyl-5H-pyrano[2,3-d:6,5-d']dipyrimidine
CAS No. 223393-69-9
项目整合开发状态: Biological Testing
项目研究机构: Katholieke Universiteit Leuven (Originator), Rega Institute for Medical Research (Originator), Saint-Petersburg State University (Originator)
合成路线:The bromination of 2,4,6-trimethylaniline (I) with Br2 in aqueous HCl gives 3-bromo-2,4,6-trimethyl-aniline (II),which is then condensed with nitrilotriacetic acid (III) by means of pyridine and acetic anhydride.
合成路线:The title pyranodipyrimidine derivative is prepared by cyclization of 4-nitrobenzylidene bis-thiobarbituric acid pyridine salt (I) employing either trifluoroacetic anhydride at 30-40 C or in lower yields with acetic anhydride at 70-80 C.The cyclization of is also carried out in the presence of POCl3/P2O5 in refluxing chloroform.
📌 参考资料/链接：
参考文献标题:5H-Pyrano[2,3-d:6,5-d']dipyrimidine derivs.having an antibacterial,antiviral and immuno-modulating activity
文献作者:Ashkinazi,R.I.(Natural Drug Sciences LLC)
参考来源:EP 1033369; US 6340755; WO 9925718
📄 详细内容
合成路线:The title pyranodipyrimidine derivative is prepared by cyclization of 4-nitrobenzylidene bis-thiobarbituric acid pyridine salt (I) employing either trifluoroacetic anhydride at 30-40 C or in lower yields with acetic anhydride at 70-80 C.The cyclization of is also carried out in the presence of POCl3/P2O5 in refluxing chloroform.
参考文献标题:Carboxylic acid anhydrides in the synthesis of 5H-pyrano[2,3-d:6,5-d']dipyrimidine derivatives
文献作者:Moskvin,A.V.; Meshcheryakov,M.P.; Reznikova,N.R.; Koz',mina,A.G.; Ivin,B.A.
参考来源:Russ J Gen Chem 2000,70(5),821
产品链接: CAS No. 223393-69-9››