新产品编号:27403
Chemical Name: 4,4'-(Piperazin-1,4-diyl)bis(benzamidine) dihydrochloride
CAS No. 123885-92-7 (free base)
项目整合开发状态: Preclinical
项目研究机构: Pace University (Originator), University of Tennessee, Memphis (Originator), Xavier University of Louisiana (Originator)
合成路线:Condensation of 4-fluorobenzonitrile (I) with piperazine (II) in hot DMSO gives rise to the dinitrile adduct (III).This is then converted into imidate (IV) with HCl/EtOH.Treatment of imidate (IV) with ethanolic ammonia furnishes the corresponding bis-amidine derivative,which is finally isolated as the dihydrochloride salt.(1,2)
📌 参考资料/链接：
参考文献标题:Trypanocidal activity of conformationally restricted pentamidine congeners
文献作者:Donkor,I.O.; Huang,T.L.; Tao,B.; Rattendi,D.; Lane,S.; Vargas,M.; Goldberg,B.; Bacchi,C.
参考来源:J Med Chem 2003,46(6),1041
📄 详细内容
合成路线:Condensation of 4-fluorobenzonitrile (I) with piperazine (II) in hot DMSO gives rise to the dinitrile adduct (III).This is then converted into imidate (IV) with HCl/EtOH.Treatment of imidate (IV) with ethanolic ammonia furnishes the corresponding bis-amidine derivative,which is finally isolated as the dihydrochloride salt.(1,2)
参考文献标题:Synthesis and anti-Pneumocystis carinii activity of conformationally restricted analogues of pentamidine
文献作者:Tao,B.; Huang,T.L.; Zhang,Q.; Jackson,L.; Queener,S.F.; Donkor,I.O.
参考来源:Eur J Med Chem 1999,34(6),531
产品链接: CAS No. 123885-92-7››