新产品编号:963947
Chemical Name: 3-[2-[6-(2-tert-Butoxyethoxy)pyridin-3-yl]-1H-imidazol-5-yl]benzonitrile hydrochloride
CAS No. 503621-43-0
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:Condensation of 6-chloronicotinonitrile (I) with 2-tert-butoxyethanol (II) employing lithium bis(trimethylsilyl)amide affords ether (III).After conversion of nitrile (III) into amidine (IV),treatment with 3-(bromoacetyl)benzonitrile (V) furnishes the title imidazole derivative.
📌 参考资料/链接：
参考文献标题:In vitro and in vivo characterization of 3-{2-[6-(2-tert-butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl}benzonitrile hydrochloride salt,a potent and selective NPY5 receptor antagonist
文献作者:Elliott,R.L.; Oliver,R.M.; Hammond,M.; Patterson,T.A.; She,L.; Hargrove,D.M.; Martin,K.A.; Maurer,T.S.; Kalvass,J.C.; Morgan,B.P.; DaSilva-Jardine,P.A.; Stevenson,R.W.; Mack,C.M.; Cassella,J.V.
参考来源:J Med Chem 2003,46(5),670