新产品编号:959201

Chemical Name: N-[2-(Dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carboxamide
CAS No. 492472-30-7
项目整合开发状态: Preclinical
项目研究机构: La Trobe University (Originator), University of Auckland (Originator)
合成路线:Reaction of ethyl (3-carboxy-8-methylquinolin-2-yl)acetate (I) with POCl3/DMF under Vilsmeier formylation conditions leads to the cyclic anhydride (II).Subsequent treatment of (II) with methylamine gives rise to the benzonaphthyridine derivative (III).After activation of acid (III) as the corresponding acyl chloride (IV) with SOCl2,condensation with N,N-dimethyl ethylenediamine (V) furnishes the title amide.