新产品编号:562119
Chemical Name: 3,9-Dibromo-12-(4-O-methyl-beta-D-glucopyranosyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
CAS No. 223750-63-8
项目整合开发状态: Biological Testing
项目研究机构: Aventis Pharma (Originator), INSERM (Originator), Novartis (Originator)
合成路线:The dechlorinated rebeccamycin anhydride (II) was prepared from rebeccamycin (I) by hydrogenolysis using Raney Nickel in aqueous sodium hydroxide.Further bromination of (II) with N-bromosuccinimide afforded dibromo derivative (III).Imide (IV) was then prepared by treatment of anhydride (III) with ammonium acetate at 180 C.
📌 参考资料/链接：
参考文献标题:Synthesis,mode of action,and biological activities of rebeccamycin bromo derivatives
文献作者:Moreau,P.; Anizon,F.; Sancelme,M.; Prudhomme,M.; Severe,D.; Riou,J.F.; Goossens,J.F.; Henichart,J.P.; Bailly,C.; Labourier,E.; Tazzi,J.; Fabbro,D.; Meyer,T.; Aubertin,A.M.
参考来源:J Med Chem 1999,42(10),1816
📄 详细内容
合成路线:The dechlorinated rebeccamycin anhydride (II) was prepared from rebeccamycin (I) by hydrogenolysis using Raney Nickel in aqueous sodium hydroxide.Further bromination of (II) with N-bromosuccinimide afforded dibromo derivative (III).Imide (IV) was then prepared by treatment of anhydride (III) with ammonium acetate at 180 C.
参考文献标题:Syntheses and biological evaluation of indolocarbazoles,analogues of Rebeccamycin,modified at the imide heterocyclic
文献作者:Moreau,P.; Anizon,F.; Sancelme,M.; Prudhomme,M.; Bailly,C.; Carrasco,C.; Ollier,M.; Severe,D.; Riou,J.F.; Fabbro,D.; Meyer,T.; Aubertin,A.M.
参考来源:J Med Chem 1998,41(10),1631