Dazolicine, UCB-B-192
达唑利辛Chemical Name: 8-Chloro-6-(1-isopropyl-4,5-dihydro-1H-imidazol-2-ylmethyl)-3,4,5,6-tetrahydro-2H-1,6-benzothiazocine
CAS No. 61477-97-2, 24484-40-0 (mono HCl salt)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The reaction of 8-chloro-3,4,5,6-tetrahydro-2H-1,6-benzothiazocine (I) with chloroacetonitrile (II) by means of Na2CO3 at 90 C gives 8-chloro-6-cyanomethyl-3,4,5,6-tetrahydro-2H-1,6-benzothiazocine (III),which is cyclized with N-isopropylethylenediamine (IV) by heating at 110 C with some CS2
📌 参考资料/链接：
参考文献标题:Dazolicine
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Koch,H.
参考来源:Drugs Fut 1981,6(9),540
📄 详细内容
合成路线:The reaction of 8-chloro-3,4,5,6-tetrahydro-2H-1,6-benzothiazocine (I) with chloroacetonitrile (II) by means of Na2CO3 at 90 C gives 8-chloro-6-cyanomethyl-3,4,5,6-tetrahydro-2H-1,6-benzothiazocine (III),which is cyclized with N-isopropylethylenediamine (IV) by heating at 110 C with some CS2
参考文献标题:
文献作者:Zivkovic,D.(UCB (Union Chimique-Chemisque Bedrijven) S.A.)
参考来源:BE 727977; CA 897161; DE 1905525; GB 1191963; JP 7213912; NL 6901745; US 366927
产品链接: CAS No. 61477-97-2››