合成路线:The condensation of 9-cyanofluorene (I) with 3-(dimethylamino)propyl chloride (II) by means of sodium amide in refluxing THF gives 9-[3-(dimethyl amino)propyl]-9-cyanofluorene (III),which is hydrolyzed partially with hot sulfuric acid water.
参考文献标题:Antiarrhythmic method
文献作者:Lacefield,W.B.; Simon,R.L.(Eli Lilly and Company)
参考来源:US 4197313
合成路线:The condensation of fluorene-9-carboxamide (IV) with acrylonitrile (V) by means of benzyltrimethylammonium hydroxide (VI) in hot dioxane gives 9-carbamoyl-9-(2-cyanoethyl)fluorene (VII),which is then hydrogenated and condensed with isopropylamine (VIII) and H2 over PtO2 with the same isopropylamine (VIII) as solvent.
参考文献标题:9-Carbamoyl-9-(2-cyanoethyl)fluorenes
文献作者:Lavagnino,E.R.; Pike,A.J.; Campbell,J.B.(Eli Lilly and Company)
参考来源:DD 158395; EP 0038676; GB 2074161; JP 1125363; US 4282170
合成路线:The condensation of 9-cyanofluorene (I) with 3-(dimethylamino)propyl chloride (II) by means of sodium amide in refluxing THF gives 9-[3-(dimethyl amino)propyl]-9-cyanofluorene (III),which is hydrolyzed partially with hot sulfuric acid water.
合成路线:The condensation of fluorene-9-carboxamide (IV) with acrylonitrile (V) by means of benzyltrimethylammonium hydroxide (VI) in hot dioxane gives 9-carbamoyl-9-(2-cyanoethyl)fluorene (VII),which is then hydrogenated and condensed with isopropylamine (VIII) and H2 over PtO2 with the same isopropylamine (VIII) as solvent.
参考文献标题:Indecainide
文献作者:Serradell,M.N.; Sneddon,J.; Castar,J.
参考来源:Drugs Fut 1985,10(2),121
产品链接: CAS No. 74517-78-5›› 产品链接: CAS No.73681-12-6››