Ro-63-0563

苯磺酰胺,4-氨基-N-[2,6-双(甲基氨基)-4-吡啶]-Chemical Name: 4-Amino-N-[2,6-bis(methylamino)pyridin-4-yl]benzenesulfonamide
CAS No. 202466-77-1
项目整合开发状态: Preclinical
项目研究机构: Roche (Originator)
合成路线:Condensation of 4-acetamidobenzenesulfonyl chloride (I) with 4-amino-2,6-dibromopyridine (II) in pyridine at 60 C afforded sulfonamide (III).The acetamido group was then hydrolyzed in refluxing 1 N NaOH to give (IV).Finally,substitution of both bromine atoms for methylamino groups was carried out by heating with liquid MeNH2 at 160 C in an autoclave.