Toloxatone, MD-69276, Umoril, Humoryl, Perenum
涛洛西酮Chemical Name: 5-(Hydroxymethyl)-3-(3-methylphenyl)oxazolidin-2-one
CAS No. 29218-27-7
项目整合开发状态: Launched-1984
项目研究机构: Delalande (Originator)
合成路线:By condensation of m-toluidine (I) and glycidol (II) in methanol to give 3-(m-toluidino)-1,2-propanediol (III),which was then cyclized by condensation with ethyl carbonate (A) by means of NaOCH3.
📌 参考资料/链接：
参考文献标题:Toloxatone
文献作者:Sungurbey,K.; Castar,J.
参考来源:Drugs Fut 1976,1(12),569
📄 详细内容
合成路线:By condensation of m-toluidine (I) and glycidol (II) in methanol to give 3-(m-toluidino)-1,2-propanediol (III),which was then cyclized by condensation with ethyl carbonate (A) by means of NaOCH3.
参考文献标题:Une nouvelle serie d'antid閜resseurs: les deriv閟 de l'hydroxym閠hyl-5-oxazolidinone-2
文献作者:Douzon,C.; Fauvan,C.
参考来源:Chimie Th閞apeutique 1973,3324-327
产品链接: CAS No. 29218-27-7››