网站主页>>>
项目整合精选>>>
项目整合精选>>>Lomefloxacin hydrochloride, SC-47111, NY-198, Okacin, Okacyn, Logiflox, Maxaquine, Maxaquin, Lomebact, Bareon, Uniquin
Lomefloxacin hydrochloride, SC-47111, NY-198, Okacin, Okacyn, Logiflox, Maxaquine, Maxaquin, Lomebact, Bareon, Uniquin
洛美沙星Chemical Name: 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride
CAS No. 98079-51-7 (free base), 114394-67-1 (mesylate salt)
项目整合开发状态: Launched-1989
项目研究机构: Abbott (Originator), Unimed (Marketer), Novartis Ophthalmics (Licensee), Pfizer (Licensee), Shionogi (Licensee)
合成路线:By condensation of 1-ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (I) with 2-methylpiperazine (II) in refluxing pyridine.
📌 参考资料/链接：
参考文献标题:Piperazinylquinoline-3-carboxylic acid derivs.
文献作者:Itoh,Y.; Kato,H.; Koshinaka,E.; Ogawa,N.; Suzuki,T.; Yagi,N.(Hokuriku Seiyaku Co.,Ltd.)
参考来源:EP 0140116; ES 8604565; ES 8609303; FR 2555584; JP 1985064979; JP 1985190777; JP 1986005075
📄 详细内容
合成路线:By condensation of 1-ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (I) with 2-methylpiperazine (II) in refluxing pyridine.
参考文献标题:NY-198
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(7),578
产品链接: CAS No. 98079-51-7›› 产品链接: CAS No.114394-67-1››