Loxoprofen sodium, CS-600G, LX-A, CS-600, Loxonin
洛索洛芬钠 洛索洛芬 Chemical Name: (?-2-[4-(2-Oxocyclopentylmethyl)phenyl]propionic acid sodium salt
CAS No. 80382-23-6, 68767-14-6 (free acid)
项目整合开发状态: Launched-1986
项目研究机构: Sankyo (Originator), Lead Chemical (Codevelopment), Toko Pharmaceutical (Codevelopment)
合成路线:The reaction of ethyl 2-oxocyclopentanecarboxylate (I) with ethyl 2-(4-chloromethylphenyl)propionate (II) by means of KOH in hot DMF gives ethyl 2-[4-(1-ethoxycarbonyl-2-oxocyclopentan-1-ylmethyl)phenyl]propionate (III),which is then hydrolyzed and decarboxylated by treatment with 47% HBr in refluxing dioxane.
📌 参考资料/链接：
参考文献标题:Substituted phenylacetic acid derivatives and process for the preparation thereof
文献作者:Misaka,E.; Terada,A.; Wachi,K.(Sankyo Co.,Ltd.)
参考来源:DE 2814556; ES 468578; FR 2395256; GB 1580113; US 4161538
📄 详细内容
合成路线:The reaction of ethyl 2-oxocyclopentanecarboxylate (I) with ethyl 2-(4-chloromethylphenyl)propionate (II) by means of KOH in hot DMF gives ethyl 2-[4-(1-ethoxycarbonyl-2-oxocyclopentan-1-ylmethyl)phenyl]propionate (III),which is then hydrolyzed and decarboxylated by treatment with 47% HBr in refluxing dioxane.
参考文献标题:Loxoprofen
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1984,9(1),22
产品链接: CAS No. 80382-23-6›› 产品链接: CAS No.68767-14-6››