合成路线:There are several synthetic pathways leading to title compound which are depicted in Scheme.Generally,1-alkyl-4,4 diphenylpiperidines Iike budipine are accessible in a simple manner and with attractive yields by a regioselective reaction of piperidine derivatives such as (I),(II),(III) or,par ticularly,3-aroyl-4-aryl-4-hydroxypiperidines (IV) with benzene under Friedel Crafts' conditions.
参考文献标题:Budipine
文献作者:Koch,H.
参考来源:Drugs Fut 1985,10(8),621
合成路线:There are several synthetic pathways leading to title compound which are depicted in Scheme.Generally,1-alkyl-4,4 diphenylpiperidines Iike budipine are accessible in a simple manner and with attractive yields by a regioselective reaction of piperidine derivatives such as (I),(II),(III) or,par ticularly,3-aroyl-4-aryl-4-hydroxypiperidines (IV) with benzene under Friedel Crafts' conditions.
参考文献标题:Synthesis physical-chemical properties and pharmacologically-oriented screening studies on budipine and related 4,4-diphenylpiperidines
文献作者:Hackmack,S.H.; et al.
参考来源:Arzneim-Forsch Drug Res 1984,34(3),233
合成路线:There are several synthetic pathways leading to title compound which are depicted in Scheme.Generally,1-alkyl-4,4 diphenylpiperidines Iike budipine are accessible in a simple manner and with attractive yields by a regioselective reaction of piperidine derivatives such as (I),(II),(III) or,par ticularly,3-aroyl-4-aryl-4-hydroxypiperidines (IV) with benzene under Friedel Crafts' conditions.
参考文献标题:4,4-Diphenylpiperidines - A new class of potent central stimulants
文献作者:Schaefer,H.; Eistetter,K.; Klosa,J.; Menge,H.G.; Hackmack,G.
参考来源:5th Intl Symp Med Chem (July 19-22,Paris) 1976,Abst 052
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