Iproplatin, NSC-256927, CHIP, JM-9
异丙铂Chemical Name: Dichlorodihydroxybis(2-propanamine)-(OC-6-33)platinum; cis-Dichloro-trans-dihydroxybis(isopropylamine)platinum(IV)
CAS No. 62928-11-4
项目整合开发状态: Phase III
项目研究机构: Johnson Matthey (Originator), Bristol-Myers Squibb (Licensee)
合成路线:Iproplatin is prepared by treating cis-dichlorobis(isopropylamine)platinum (I) with hydrogen peroxide,mixing the product by N,N-dimetylacetamide at 5 C to give iproplatin-dimethylacetamide 1:1 addiction product (II).After elimination of N,N-dimethylacetamide by heating (II) at 50 C / 0.1 torr iproplatin is obtained.
📌 参考资料/链接：
参考文献标题:cis-Dichloro-trans-dihydroxy-bis(isopropylamine)platinum(IV),preparation and intermediate
文献作者:Hepburn,D.R.; Hydes,P.C.(Johnson Matthey plc)
参考来源:BE 890209; JP 1982077694
📄 详细内容
合成路线:Iproplatin is prepared by treating cis-dichlorobis(isopropylamine)platinum (I) with hydrogen peroxide,mixing the product by N,N-dimetylacetamide at 5 C to give iproplatin-dimethylacetamide 1:1 addiction product (II).After elimination of N,N-dimethylacetamide by heating (II) at 50 C / 0.1 torr iproplatin is obtained.
参考文献标题:Iroplatin
文献作者:Chang,P.
参考来源:Drugs Fut 1985,10(7),561
产品链接: CAS No. 62928-11-4››