Isbufylline, TE-06
异丁茶碱Chemical Name: 7-Isobutyltheophylline; 1,3-Dimethyl-7-isobutylxanthine; 1,3-Dimethyl-7-isobutyl-3,7-dihyro-1H-purine-2,6-dione
CAS No. 90162-60-0
项目整合开发状态: Phase II
项目研究机构: Malesci (Originator), Menarini (Licensee)
合成路线:By reaction of theophylline sodium salt with isobutyl halogenide in N,N-dimethylformamide at 80 C.
📌 参考资料/链接：
参考文献标题:Xanthine derivs.,pharmaceutical compsns.containing same and their therapeutic use
文献作者:Fedi,M.; Bonacchi,G.(Malesci Ist.Farmacobiol.SpA)
参考来源:US 4544556
📄 详细内容
合成路线:By reaction of theophylline sodium salt with isobutyl halogenide in N,N-dimethylformamide at 80 C.
参考文献标题:Crystal structure of a new antibronchospastic drug: 1,3-dimethyl-7-isobutylxanthine (TE 06)
文献作者:Bonacchi,G.; Manzini,S.; Dapporto,P.; Paoli,P.
参考来源:In: Three-Dimensional Molecular Structure and Drug Action - 15th Course of International School of Crystallography (June 1-11,Erice) 1989,Poster No.8
合成路线:By reaction of theophylline sodium salt with isobutyl halogenide in N,N-dimethylformamide at 80 C.
参考文献标题:ISBUFYLLINE
文献作者:Manzini,S.; Fedi,M.; Bonacchi,G.; Agostini,O.
参考来源:Drugs Fut 1990,15(3),228
产品链接: CAS No. 90162-60-0››