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项目整合精选>>>Nimesulide, NIM-03, R-805, Nise Gel, Orthobid, Guaxan, Antifloxil, Nimedex, Nisulid, Nimed, Aldoron, Mesulid, Aulin
Nimesulide, NIM-03, R-805, Nise Gel, Orthobid, Guaxan, Antifloxil, Nimedex, Nisulid, Nimed, Aldoron, Mesulid, Aulin
尼美舒利Chemical Name: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
CAS No. 51803-78-2
项目整合开发状态: Launched-1985
项目研究机构: Boehringer Ingelheim (Originator), Helsinn (Originator), LPB (Originator), Alter (Marketer), Italfarmaco (Licensee), Roche (Licensee)
合成路线:Compound can be prepared in three different ways:1) By nitration of 2-phenoxymethanesulfonanilide (I) with nitric acid in acetic acid.2) By condensation of 2-phenoxy-4-nitroaniline (II) with methanesulfonyl chloride in pyridine.3) By condensation of 2-bromo-4-nitromethanesulfonanilide (III) with phenol (A) by means of KOH and pyridine in benzene.
📌 参考资料/链接：
参考文献标题:R-805
文献作者:Castar,J.; Chatterjee,S.S.
参考来源:Drugs Fut 1976,1(3),145
📄 详细内容
合成路线:Compound can be prepared in three different ways:1) By nitration of 2-phenoxymethanesulfonanilide (I) with nitric acid in acetic acid.2) By condensation of 2-phenoxy-4-nitroaniline (II) with methanesulfonyl chloride in pyridine.3) By condensation of 2-bromo-4-nitromethanesulfonanilide (III) with phenol (A) by means of KOH and pyridine in benzene.
参考文献标题:Substituted 2-phenoxy alkanesulfonanilides
文献作者:Moore,G.; Harrington,J.K.
参考来源:US 3840597
合成路线:Compound can be prepared in three different ways:1) By nitration of 2-phenoxymethanesulfonanilide (I) with nitric acid in acetic acid.2) By condensation of 2-phenoxy-4-nitroaniline (II) with methanesulfonyl chloride in pyridine.3) By condensation of 2-bromo-4-nitromethanesulfonanilide (III) with phenol (A) by means of KOH and pyridine in benzene.
参考文献标题:2-Phenoxy alkyl sulphonalides
文献作者:
参考来源:DE 2333643; FR 2190460; GB 1435755; JP 57136560; JP 57140712
产品链接: CAS No. 51803-78-2››