Nisoldipine, Bay-k-5552, Sular, Baymycard, Syscor
尼索地平Chemical Name: (?-2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid methyl 2-methylpropyl diester
CAS No. 63675-72-9
项目整合开发状态: Launched-1990
项目研究机构: Bayer (Originator), Pharmax (Not Determined), AstraZeneca (Licensee)
合成路线:By cyclization of isobutyl 2-(2-nitrobenzylidene)acetoacetate (I) and methyl 3-aminocrotonate (II) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
文献作者:Wehinger,E.; et al.(Bayer AG)
参考来源:US 4154839
📄 详细内容
合成路线:By cyclization of isobutyl 2-(2-nitrobenzylidene)acetoacetate (I) and methyl 3-aminocrotonate (II) in refluxing ethanol.
参考文献标题:Nisoldipine
文献作者:McGillion,F.B.; Castar,J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1981,6(6),360
产品链接: CAS No. 63675-72-9››