合成路线:4) The reaction of gentamicin C1a (I) with formaldehyde in ethanol gives 6'-N-methylenegentamicin C1a (III),which is then reduced with NaBH4,or with hot formic acid.5) The reaction of gentamicin C1a (I) with ethyl chloroformate (C) by means of NaOH in dioxane yields ethyl 6'-carbamategentamicin C1a (IV),which is then reduced with LiAlH4 in THF.
参考文献标题:
文献作者:Matsushima,H.; et al.
参考来源:JP 75149647
合成路线:4) The reaction of gentamicin C1a (I) with formaldehyde in ethanol gives 6'-N-methylenegentamicin C1a (III),which is then reduced with NaBH4,or with hot formic acid.5) The reaction of gentamicin C1a (I) with ethyl chloroformate (C) by means of NaOH in dioxane yields ethyl 6'-carbamategentamicin C1a (IV),which is then reduced with LiAlH4 in THF.
参考文献标题:
文献作者:Matsushima,H.; et al.
参考来源:JP 75149646
合成路线:4) The reaction of gentamicin C1a (I) with formaldehyde in ethanol gives 6'-N-methylenegentamicin C1a (III),which is then reduced with NaBH4,or with hot formic acid.5) The reaction of gentamicin C1a (I) with ethyl chloroformate (C) by means of NaOH in dioxane yields ethyl 6'-carbamategentamicin C1a (IV),which is then reduced with LiAlH4 in THF.
参考文献标题:
文献作者:Matsushima,H.; et al.
参考来源:JP 75131949
合成路线:1) By methylation of gentamicin C1a (I) with methyl p-toluenesulfonate (A) in acetonitrile.2) By methylation of gentamicin C1a (I) with methyl bromide (B) in methanol.3) The reaction of gentamicin C1a (I) with CS2 in ethanol gives the 6'-N-dithiocarbamylgentamicin (II),C1a which is reduced with LiAlH4 in refluxing THF.
参考文献标题:
文献作者:Matsushima,H.; et al.
参考来源:JP 75123640
合成路线:1) By methylation of gentamicin C1a (I) with methyl p-toluenesulfonate (A) in acetonitrile.2) By methylation of gentamicin C1a (I) with methyl bromide (B) in methanol.3) The reaction of gentamicin C1a (I) with CS2 in ethanol gives the 6'-N-dithiocarbamylgentamicin (II),C1a which is reduced with LiAlH4 in refluxing THF.
参考文献标题:
文献作者:Matsushima,H.; et al.
参考来源:JP 75129531
合成路线:1) By methylation of gentamicin C1a (I) with methyl p-toluenesulfonate (A) in acetonitrile.2) By methylation of gentamicin C1a (I) with methyl bromide (B) in methanol.3) The reaction of gentamicin C1a (I) with CS2 in ethanol gives the 6'-N-dithiocarbamylgentamicin (II),C1a which is reduced with LiAlH4 in refluxing THF.
合成路线:4) The reaction of gentamicin C1a (I) with formaldehyde in ethanol gives 6'-N-methylenegentamicin C1a (III),which is then reduced with NaBH4,or with hot formic acid.5) The reaction of gentamicin C1a (I) with ethyl chloroformate (C) by means of NaOH in dioxane yields ethyl 6'-carbamategentamicin C1a (IV),which is then reduced with LiAlH4 in THF.
参考文献标题:Sagamicin
文献作者:Castar,J.; Sweetman,A.J.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1979,4(5),360
产品链接: CAS No. 52093-21-7››