合成路线:By reaction of theophylline-7-acetaldehyde (I) with ethylene glycol (II) by means of p-toluenesulfonic acid in refluxing benzene.
合成路线:Condensation of 1-(b-L-ribofuranosyl)thymine (XXXVI) with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (XXXVII) in pyridine gives the cyclic disiloxane nucleoside (XXXVIII),which is acylated with thiocarbonyldiimidazole (TCDI) in DMF to yield the 2'-O-thioester derivative (XXXIX).Reduction of this compound by means of 2,2'-azobis(methylpropionitrile) (ABMP) and Bu3SnH in refluxing toluene affords the silylated 2'-deoxynucleoside (XL),which is finally desilylated by means of TBAF in THF.
参考文献标题:Dimeric cpds.and their use as anti-viral agents
文献作者:Dowle,M.D.; Wu,W.-Y.; Jin,B.; Mason,A.M.; McConnell,D.; MacDonald,S.J.F.; Shanahan,S.E.; Nguyen,V.T.T.(Biota Scientific Management Pty Ltd.)
参考来源:WO 0340135
合成路线:By reaction of theophylline-7-acetaldehyde (I) with ethylene glycol (II) by means of p-toluenesulfonic acid in refluxing benzene.
参考文献标题:Diossolani ed 1,3-diossani
文献作者:De Martiis,F.; Toffoli,F.; Avico,U.
参考来源:Farm Sci Ed 1962,1773-80
合成路线:By reaction of theophylline-7-acetaldehyde (I) with ethylene glycol (II) by means of p-toluenesulfonic acid in refluxing benzene.
参考文献标题:Pharmacoligical researches on 2-(7'-theophyllinemethyl)-1,3-dioxolane
文献作者:Franzone,J.S.; Di Carlo,R.; Fonzo,D.; Reboani,C.
参考来源:Farm Sci Ed 1981,36201-219
产品链接: CAS No. 69975-86-6››