Dromoprednate, Ro-12-7024
多泼尼酯Chemical Name: 11beta-Hydroxy-17a-(1-oxobutoxy)-D-homopregna-1,4-diene-3,20-dione; 11beta,17aalpha-Dihydroxy-D-homopregna-1,4-diene-3,20-dione 17a-butyrate; 17aalpha-Butyryloxy-11beta-hydroxy-D-homopregna-1,4-diene-3,20-dione
CAS No. 66877-67-6
项目整合开发状态: Biological Testing
项目研究机构: Roche (Originator)
合成路线:The partial acylation of 11beta,17a alpha(dihydroxy-D-homopregna-1,4-diene 3,20-dione (I) with 2,2-dichloroacetyl chloride gives the corresponding compound (II),which is acylated again with butyric anhydride yielding 17a alpha-butyryloxy-11beta-dichloroacetoxy-D-homopregna-1,4-diene-3,20-dione (III).Finally,this compound is hydrolyzed partially with aqueous NH4OH and methanol.
📌 参考资料/链接：
参考文献标题:D-Homopregnanes
文献作者:F黵st,A.; Alig,L.; Kerb,U.; M黮ler,M.; Wiechert,R.; Kieslich,K.(Hoffmann-La Roche,Inc.)
参考来源:US 4202841
📄 详细内容
合成路线:The partial acylation of 11beta,17a alpha(dihydroxy-D-homopregna-1,4-diene 3,20-dione (I) with 2,2-dichloroacetyl chloride gives the corresponding compound (II),which is acylated again with butyric anhydride yielding 17a alpha-butyryloxy-11beta-dichloroacetoxy-D-homopregna-1,4-diene-3,20-dione (III).Finally,this compound is hydrolyzed partially with aqueous NH4OH and methanol.
参考文献标题:Domoprednate
文献作者:Baines,A.; M黮ler,M.
参考来源:Drugs Fut 1987,12(2),118
产品链接: CAS No. 66877-67-6››