Doxacurium chloride, BW-A938U, Nuromax
多库酯钠Chemical Name: trans,trans-2,2'-[(1,4-Dioxo-1,4-butanediyl)bis(oxy-3,1-propanediyl)]bis[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolinium] dichloride; (1R,2S,1S,2R)-2-(3-Hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium chloride,succinate (2:1); trans,trans-2,2'-[Dimethylenebis(carbonyloxytrimethylene)]bis[1,2,3,4,-tetrahydro-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium]dichloride
CAS No. 106819-53-8, 83348-52-1 (racemate), 106791-39-3 (racemic, free base)
项目整合开发状态: Launched-1991
项目研究机构: GlaxoSmithKline (Originator), Abbott (Licensee)
合成路线:5',8-Dimethoxylaudanosine (I) is condensed with 3-iodopropanol (II) in refluxing acetone and passed through Dowex 1-X8 ion exchange resin to give trans-N-(3-hydroxypropyl)-5',8-dimethoxylaudanosinium chloride (III),which is then esterified with succinyl chloride (IV) in refluxing dichloroethane.
📌 参考资料/链接：
参考文献标题:Long duration neuromuscular blocking agents,pharmaceutical compsns.containing them and processes for their preparation
文献作者:El-Sayad,H.A.; Yeowell,D.A.; Swaringen,R.A.Jr.(GlaxoSmithKline plc)
参考来源:EP 0054309; US 4701460
📄 详细内容
合成路线:5',8-Dimethoxylaudanosine (I) is condensed with 3-iodopropanol (II) in refluxing acetone and passed through Dowex 1-X8 ion exchange resin to give trans-N-(3-hydroxypropyl)-5',8-dimethoxylaudanosinium chloride (III),which is then esterified with succinyl chloride (IV) in refluxing dichloroethane.
参考文献标题:DOXACURIUM CHLORIDE < Rec INN; BAN >
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(3),211
产品链接: CAS No. 106819-53-8››