Dopexamine, FPL-60278
多培沙明盐酸多培沙明Chemical Name: 4-[2-[[6-[(2-Phenylethyl)amino]hexyl]amino]ethyl]-1,2-benzenediol; 4-[2-[[(6-Phenethylamino)hexyl]amino]ethyl]pyrocathecol; N-(2-Phenylethyl)-N'-[2-(3,4-dihydroxyphenyl)ethyl]hexane-1,6-diamine
CAS No. 86197-47-9, 86484-52-8 (diHBr), 86484-91-5 (diHCl)
项目整合开发状态: Launched-1989
项目研究机构: AstraZeneca (Originator)
合成路线:The condensation of 6-oxo-6-[2-(3,4-dimeth oxyphenyl)ethylaminolhexanoic acid (I) with 2-phenylethylamine (II) by means of N,N'-carbonyldiimidazole in CH2Cl2 gives N-[2-(3,4-dimethoxyphenyl)ethyl]-N'-(2'-phenylethyl)hexane-1,6-diamide (III),which is reduced by means of diborane in THF yielding N-[2-(3,4 dimethoxyphenyl)ethyl-N'-(2-phenylethyl)hexane-1,6-diamine (IV).Finally,this compound is demethylated by means of refluxing 48% aqueous HBr.
📌 参考资料/链接：
参考文献标题:Phenylethylamine derivatives and pharmaceutical use
文献作者:Farmer,J.B.; Ince,F.; Brown,R.A.; Dixon,J.(Rh鬾e-Poulenc Rorer Ltd.)
参考来源:CA 1191846; EP 0072061; US 5013760
📄 详细内容
合成路线:The condensation of 6-oxo-6-[2-(3,4-dimeth oxyphenyl)ethylaminolhexanoic acid (I) with 2-phenylethylamine (II) by means of N,N'-carbonyldiimidazole in CH2Cl2 gives N-[2-(3,4-dimethoxyphenyl)ethyl]-N'-(2'-phenylethyl)hexane-1,6-diamide (III),which is reduced by means of diborane in THF yielding N-[2-(3,4 dimethoxyphenyl)ethyl-N'-(2-phenylethyl)hexane-1,6-diamine (IV).Finally,this compound is demethylated by means of refluxing 48% aqueous HBr.
参考文献标题:Dopexamine
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1985,10(8),628
产品链接: CAS No. 86197-47-9›› 产品链接: CAS No.86484-91-5››