Flavalfate, Dosmalfate, F-3616M, F-3616, Diotul

多司马酯Chemical Name: [mu7-[7-[[6-O-(6-Deoxy-2,3,4-tri-O-sulfo-alpha-L-mannopyranosyl)-2,3,4-tri-O-sulfo-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-[4-methoxy-3-(sulfooxy)phenyl]-4H-1-benzopyran-4-onato(7-)]]tetradeca-mu-hydroxyheneicosahydroxytetradecaaluminum; [mu7-[[Diosmin heptasulfato](7-)]]tetracontahydroxytetradecaaluminium
CAS No. 122312-55-4
项目整合开发状态: Launched-2000
项目研究机构: FAES (Originator)
合成路线:Dosmalfate is obtained in a multistep synthesis:The treatment of anhydrous 5-ethyl-2-methylpyridine (I) with chlorosulfonic acid (II) affords 5-ethyl-2-methylpyridine sulfur trioxide complex (III).Heating 1 mol of diosmin (IV) with 7 mol of (III) gives diosmin heptakis(hydrogensulfate) 5-ethyl-2-methylpyridinium salt (V),which by treatment with aqueous sodium hydroxide yields the diosmin heptakis(hydrogensulfate) sodium salt.Finally,the reaction of the sodium salt in an aqueous medium with an aqueous aluminum hydroxychloride solution yields the diosmin heptakis(hydrogensulfate) aluminum complex.