Eticlopride hydrochloride, A-38503, FLB-131

R(+)-盐酸埃替普利Chemical Name: (-)-(S)-3-Chloro-5-ethyl-N-(1-ethylpyrrolidin-2-ylmethyl)-6-hydroxy-2-methoxybenzamide hydrochloride; (-)-(S)-N-Ethyl-2-(3-chloro-5-ethyl-6-hydroxy-2-methoxybenzamidomethyl)pyrrolidine hydrochloride; (-)-(S)-5-Chloro-3-ethyl-N-(1-ethylpyrrolidin-2-ylmethyl)-6-methoxysalicylamide hydrochloride
CAS No. 84226-12-0 (free base)
项目整合开发状态: Preclinical
项目研究机构: AstraZeneca (Originator)
合成路线:The reaction of 3-chloro-5-ethyl-2,6-dimethoxybenzoic acid (I) with SOCl2 gives the corresponding acyl chloride (II),which is condensed with N-ethyl-2-(aminomethyl)pyrrolidine (III) in refluxing CHCl3 yielding N-ethyl-2-(3-chloro-5-ethyl-2,6-dimethoxybenzamidomethyl)pyrrolidine (IV).Finally,this compound is treated with BBr3 in methylene chloride.

合成路线:The reaction of 3,5-dichloro-6-methoxysaliclic acid (I) with refluxing SOCl2 gives the corresponding acyl chloride (II),which is condensed with 1-ethyl-2-(aminomethyl)pyrrolidine (III) in methylene chloride yielding the amide (IV).Finally,this compound is partially demethylated with BBr3 in methylene chloride ether.