NU-2058
O6-环甲基己基鸟嘌呤Chemical Name: 6-(Cyclohexylmethoxy)-9H-purin-2-ylamine; 6-(Cyclohexylmethyl)guanine
CAS No. 161058-83-9
项目整合开发状态: Biological Testing
项目研究机构: AstraZeneca (Originator), University of Newcastle upon Tyne (Originator)
合成路线:The reaction of 2-amino-6-chloropurine (I) with 1,4-diazabicyclo[2.2.2]octane (II) in DMSO gives 1-(2-aminopurin-6-yl)-4-aza-1-azoniabicyclo[2.2.2]octane chloride (II),which is condensed with cyclohexylmethanol (III) by means of NaH in DMSO.
📌 参考资料/链接：
参考文献标题:Cyclin dependent kinase inhibiting purine derivs.
文献作者:Boyle,F.T.; Curtin,N.J.; Calvert,A.H.; Jewsbury,P.J.; Endicott,J.A.; Noble,M.E.M.; Griffin,R.J.; Golding,B.T.; Newell,D.R.(University of Newcastle upon Tyne)
参考来源:EP 1017394; WO 9902162
📄 详细内容
合成路线:The reaction of 2-amino-6-chloropurine (I) with 1,4-diazabicyclo[2.2.2]octane (II) in DMSO gives 1-(2-aminopurin-6-yl)-4-aza-1-azoniabicyclo[2.2.2]octane chloride (II),which is condensed with cyclohexylmethanol (III) by means of NaH in DMSO.
参考文献标题:Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group
文献作者:Lembicz,N.K.; et al.
参考来源:J Chem Soc - Perkins Trans I 1997,(3),185
合成路线:The reaction of 2-amino-6-chloropurine (I) with 1,4-diazabicyclo[2.2.2]octane (II) in DMSO gives 1-(2-aminopurin-6-yl)-4-aza-1-azoniabicyclo[2.2.2]octane chloride (II),which is condensed with cyclohexylmethanol (III) by means of NaH in DMSO.
参考文献标题:Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles
文献作者:Arris,C.E.; Boyle,F.T.; Calvert,A.H.; Curtin,N.J.; Endicott,J.A.; Garman,E.F.; Gibson,A.E.; Golding,B.T.; Grant,S.; Griffin,R.J.; Jewsbury,P.; Johnson,L.N.; Lawrie,A.M.; Newell,D.R.; Noble,M.E.; Sausville,E.A.; Schultz,R.M.; Yu,W.
参考来源:J Med Chem 2000,43(15),2797
产品链接: CAS No. 161058-83-9››