AC-178335
N-乙酰-D-组胺基-D-苯丙氨酸-D-异端乙酰-D-精氨酸-D-色氨酸-D-苯丙氨酸酰Chemical Name: N-Acetyl-D-histidyl-D-phenylalanyl-D-isoleucyl-D-arginyl-D-tryptophyl-D-phenylalaninamide
CAS No. 212966-15-9
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:This peptide has been obtained by by the usual method of solid phase resin starting from N-Boc-protected D-phenylalanine coupled to a methylbenzhydryl amine polystyrene resin (I) by successive cycles of Boc deprotection and coupling.The amino acid used were successively,N-Boc-D-tryptophan (II),N-Boc-D-arginine (IV),N-Boc-D-isoleucine (VI),N-Boc-D-phenylalanine (VIII) and N-Boc-D-histidine (X),yielding the intermediate peptide-resins (III),(V),(VII),(IX),and (XI).Finally,this last intermediate was deprotected and cleaved from the resin with HF,acetylated at the N-terminus and amidated at the C-terminus using standard methods.
📌 参考资料/链接：
参考文献标题:Peptides useful as somatostatin antagonists
文献作者:Houghten,R.A.; Baumbach,W.R.(American Cyanamid Co.)
参考来源:EP 0863156
📄 详细内容
合成路线:This peptide has been obtained by by the usual method of solid phase resin starting from N-Boc-protected D-phenylalanine coupled to a methylbenzhydryl amine polystyrene resin (I) by successive cycles of Boc deprotection and coupling.The amino acid used were successively,N-Boc-D-tryptophan (II),N-Boc-D-arginine (IV),N-Boc-D-isoleucine (VI),N-Boc-D-phenylalanine (VIII) and N-Boc-D-histidine (X),yielding the intermediate peptide-resins (III),(V),(VII),(IX),and (XI).Finally,this last intermediate was deprotected and cleaved from the resin with HF,acetylated at the N-terminus and amidated at the C-terminus using standard methods.
参考文献标题:A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats
文献作者:Baumbach,W.R.; Carrick,T.A.; Pausch,M.H.; Bingham,B.; Carmignac,D.; Robinson,I.C.A.F.; Houghten,R.; Eppler,C.M.; Price,L.A.; Zysk,J.R.
参考来源:Mol Pharmacol 1998,54(5),864
产品链接: CAS No. 212966-15-9››