CL-259763

N-[4-(4-氟苯基)磺酰基苯基]乙酰胺Chemical Name: N-[4-(4-Fluorophenylsulphonyl)phenyl]acetamide
CAS No. 734-22-5
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:1) The reaction of p-fluorothiophenol (I) with p-chloronitrobenzene (II) in 50% aqueous ethanol in the presence of sodium carbonate gives p-fluorophenyl-p-nitrophenyl sulfide (III),which is then oxidized with 30% aqueous hydrogen peroxide in glacial acetic acid to give the corresponding sulfone (IV).The catalytic reduction of the sulfone (IV) with Raney Nickel in p-dioxane affords p-(p-fluorophenylsulfonyl)aniline (V),which is then acetylated with acetic anhydride in tetrahydrofuran to give title compound.

合成路线:2) The reaction of fluorobenzene (VI) with N-acetylsulfanilyl chloride (VII) in the presence of anhydrous aluminum chloride gives the desired acetamide in one step.