Elinafide mesilate, LU-79553
依利奈法德 Chemical Name: N,N'-Bis[2-(1,8-naphthalimido)ethyl]-1,3-diaminopropane dimethanesulfonate; N,N'-Bis[2-(1,3-dioxo-2,3-dihydro-1H-benz[de]isoquinolin-2-yl)ethyl]-1,3-diaminopropane dimethanesulfonate; 2,2'-Propane-1,3-diylbis(iminoethylene)bis(2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione) dimethanesulfonate
CAS No. 162706-56-1 (acetate), 162706-37-8 (free base), 162706-57-2 (mesylate), 189336-92-3 (monoacetate), 189336-91-2 (monomesylate)
项目整合开发状态: Phase II
项目研究机构: Abbott (Originator)
合成路线:By condensation of 1,8-naphthalic anhydride (I) wih N,N?bis(2-aminoethyl)propane-1,2-diamine (II) in refluxing dioxane,or in hot NMM.
📌 参考资料/链接：
参考文献标题:New bis-naphthalimides for the treatment of cancer
文献作者:Keilhauer,G.; Romerdahl,C.; Bra馻,M.F.; Qian,X.-D.; Bousquet,P.; Castellano Berlanga,J.M.; Moran Moset,M.; Perez De Vega,M.J.(BASF AG)
参考来源:EP 0714387; JP 1997501662; US 5616589; WO 9505365
📄 详细内容
合成路线:By condensation of 1,8-naphthalic anhydride (I) wih N,N?bis(2-aminoethyl)propane-1,2-diamine (II) in refluxing dioxane,or in hot NMM.
参考文献标题:Method for producing aromatic bisimides
文献作者:Koser,S.; Viergutz,W.(BASF AG)
参考来源:DE 19720803; WO 9852924
合成路线:By condensation of 1,8-naphthalic anhydride (I) wih N,N?bis(2-aminoethyl)propane-1,2-diamine (II) in refluxing dioxane,or in hot NMM.
参考文献标题:Bis-naphthalimides 3: Synthesis and antitumor activity of N,N'-bis[2-(1,8-naphthalimido)-ethyl]alkanediamines
文献作者:Bra馻,M.F.; et al.
参考来源:Anti-Cancer Drug Des 1996,11(4),297
产品链接: CAS No.162706-37-8››