Eptapirone, L-0068, F-11440
依他匹隆 Chemical Name: 4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione
CAS No. 179756-58-2, 179756-85-5 (monofumarate salt)
项目整合开发状态: Phase II
项目研究机构: Pierre Fabre (Originator)
合成路线:Triazinone (I) was alkylated with 1-bromo-4-chlorobutane (II) in the presence of NaH to give the (chlorobutyl)triazinone (III).Subsequent hydrolysis of (III) with boiling 2 N HCl provided triazinedione (IV).Finally,condensation of (IV) with 1-(2-pyrimidinyl)piperazine (V) yielded the title compound.
📌 参考资料/链接：
参考文献标题:S.A.R.of a novel series of high efficacy 5HT1A ag
文献作者:Colpaert,F.C.; Koek,W.; Kleven,M.; Assie,M.B.; Dupont-Passelaigue,E.; Rouais,C.; Blettery,J.L.; Cosi,C.; Patoiseau,J.E.
参考来源:15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998,Edinburgh) 1998,Abst P.296