Dicloguamine maleate, Irsogladine maleate, MN-1695, Gaslon
伊索拉定 6-(2,5-二氯苯基)-1,3,5-三嗪-2,4-二胺马来酸盐Chemical Name: 2,4-Diamino-6-(2,5-dichlorophenyl)-s-triazine maleate; 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine (Z)-2-butenedioate
CAS No. 57381-33-6, 57381-26-7 (free base), 57381-28-9 (monoHBr), 57381-27-8 (monoHCl)
项目整合开发状态: Launched-1989
项目研究机构: Nippon Shinyaku (Originator), TaeJoon Pharm. (Licensee)
合成路线:This compound can be obtained by two different ways:1) By cyclization of 2,5-dichlorobenzonitrile (I) with dicyandiamide (II) with KOH in refluxing methyl cellosolve,followed by treatment with maleic acid in dioxane.2) By treatment of 2,4-dichloro-6-(2,5-dichlorophenyl)-s-triazine (III) with 28% aqueous ammonia at 100 C.
📌 参考资料/链接：
参考文献标题:Benzoguanamine derivatives
文献作者:Murai,H.; Ohata,K.; Aoyagi,Y.; Ueda,F.; Kitano,M.; Takata,S.; Toda,S.(Nippon Shinyaku Co.,Ltd.)
参考来源:CH 592638; DE 2506814; FR 2261009; GB 1441904; JP 77111086; JP 7746955; NL 7501575; US 3966728
📄 详细内容
合成路线:This compound can be obtained by two different ways:1) By cyclization of 2,5-dichlorobenzonitrile (I) with dicyandiamide (II) with KOH in refluxing methyl cellosolve,followed by treatment with maleic acid in dioxane.2) By treatment of 2,4-dichloro-6-(2,5-dichlorophenyl)-s-triazine (III) with 28% aqueous ammonia at 100 C.
参考文献标题:Dihalobenzoguanamines with anti-ulcus activity
文献作者:Murai,H.; Ohata,K.; Aoyagi,Y.; Ueda,F.(Nippon Shinyaku Co.,Ltd.)
参考来源:CH 596193; JP 51075083; NL 7514062
合成路线:This compound can be obtained by two different ways:1) By cyclization of 2,5-dichlorobenzonitrile (I) with dicyandiamide (II) with KOH in refluxing methyl cellosolve,followed by treatment with maleic acid in dioxane.2) By treatment of 2,4-dichloro-6-(2,5-dichlorophenyl)-s-triazine (III) with 28% aqueous ammonia at 100 C.
参考文献标题:MN-1695
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1983,8(6),502
产品链接: CAS No.57381-26-7›› 产品链接: CAS No.57381-28-9››