ADD-233089, AWD-131-138

伊匹妥英Chemical Name: 1-(4-Chlorophenyl)-4-(4-morpholinyl)-2,5-dihydro-1H-imidazol-2-one
CAS No. 188116-07-6
项目整合开发状态: Phase I
项目研究机构: elbion (Originator)
合成路线:The synthesis of AWD 131-138 is obtained as illustrated in Scheme 25002101a:The alkylation of 4-chloroaniline (I) with chloroacetic acid methyl ester in ethanol gives N-(4-chlorophenyl)glycine methyl ester (II),which is added to cyanate by means of hydrochloric acid in glacial acetic acid to yield 3-(4-chlorophenyl)hydantoic acid methyl ester (III).The cyclization in hydrochloric acid yields 1-(4-chlorophenyl)hydantoin (IV),which is finally condensed with morpholine.