AT-1015
N-[2-[4-(二苯并[a,d]环庚-5-瘂烯)哌啶-1-基]乙基]-1-甲基哌啶-4-羧酰胺盐酸水合物Chemical Name: N-[2-[4-(Dibenzo[a,d]cyclohepten-5-ylidene)piperidin-1-yl]ethyl]-1-formylpiperidine-4-carboxamide hydrochloride hydrate
CAS No. 190508-48-6
项目整合开发状态: Discontinued
项目研究机构: Ajinomoto (Originator)
合成路线:2-Bromoethylamine (I) was protected as the Boc derivative (II) and then condensed with dibenzocycloheptenylidenepiperidine (III) to afford (IV).Acid deprotection of the Boc group of (IV) provided diamine (V).This was then coupled with N-formyl isonipecotic acid (VI) employing EDC to produce the corresponding amide.The title compound was finally converted to the hydrochloride salt.
📌 参考资料/链接：
参考文献标题:Piperidine derivates and anti-platelet agents containing the same
文献作者:Makino,S.; Arisaka,H.; Yamamoto,H.; Shoji,M.; Yoshimoto,R.(Ajinomoto Co.,Inc.)
参考来源:CA 2147429; EP 0682015; JP 1996003135; JP 1999246526; US 5932593
📄 详细内容
合成路线:2-Bromoethylamine (I) was protected as the Boc derivative (II) and then condensed with dibenzocycloheptenylidenepiperidine (III) to afford (IV).Acid deprotection of the Boc group of (IV) provided diamine (V).This was then coupled with N-formyl isonipecotic acid (VI) employing EDC to produce the corresponding amide.The title compound was finally converted to the hydrochloride salt.
参考文献标题:Crystals of piperidine derivs.,intermediates for production of the same,and process for producing the same
文献作者:Yamamoto,T.; Asai,K.; Fujii,A.; Naora,H.; Kubo,M.; Mihara,R.; Shimada,J.(Ajinomoto Co.,Inc.)
参考来源:EP 0770602
产品链接: CAS No. 190508-48-6››