新产品编号:471945
N-[2-[4-(4-氯苯)吡喃嗪-1-基]乙基]-3-甲氧基苯甲酰胺Chemical Name: N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide
CAS No. 219125-63-0
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Bari (Originator)
合成路线:Treatment of 3-methoxybenzoic acid (I) with methyl chloroformate and triethylamine produced the mixed anhydride (II),which was condensed with amine (III) to provide the title amide.
📌 参考资料/链接：
参考文献标题:N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: A potent and selective dopamine D4 ligand
文献作者:Perrone,R.; Berardi,F.; Colabufo,N.A.; Leopoldo,M.; Tortorella,V.
参考来源:J Med Chem 1998,41(24),4903
📄 详细内容
合成路线:The condensation of 1-(4-chlorophenyl)piperazine (I) with 2-chloroacetonitrile (II) gives 2-[4-(4-chlorophenyl)-1-piperazinyl]acetonitrile (III),which is reduced with borane/dimethylsulfide yielding the corresponding primary amine (IV).Finally,(IV) is condensed with 3-methoxybenzoyl chloride.
参考文献标题:A structure-affinity relationship study on derivatives of N-[2-[4-(chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide,a high-affinity and selective D4 receptor ligand
文献作者:Perrone,R.; Berardi,F.; Colabufo,N.A.; Leopoldo,M.; Tortorella,V.
参考来源:J Med Chem 2000,43(2),270
产品链接: CAS No. 219125-63-0››