PMS-601, MFH-1

N,N-二乙基甲酰胺酸1,4-双(3,4,5-三甲氧基苯甲酰基)哌嗪-2-基-甲基酯)Chemical Name: N,N-Diethylcarbamic acid 1,4-bis(3,4,5-trimethoxybenzoyl)piperazin-2-ylmethyl ester
CAS No. 158978-98-4
项目整合开发状态: Preclinical
项目研究机构: BTG (Proprietary), Universit?Denis Diderot-Paris 7 (Originator)
合成路线:The esterification of 1,4-dibenzyl-2-(hydroxymethyl)piperazine (I) with diphenyl carbonate and triethylamine in dichloromethane gives the mixed carbonate ester (II),which is treated with refluxing diethylamine to yield the carbamate ester (III).The deprotection of (III) with H2 over Pd/C in ethanol/HCl affords N,N-diethylcarbamic acid piperazin-2-ylmethyl ester (IV),which is finally condensed with 3,4,5-trimethoxybenzoyl chloride (V) by means of triethylamine in dichloromethane.