Cistinexine, Rec-15-1884
N,N'-二[(苄氧基)羰基]-N,N'-二(2,4-二溴-6-{[环己基(甲基)氨基]甲基}苯基)-L-半胱氨酰锡酰胺Chemical Name: Dibenzyl[dithiobis[(R)-1-[[4,6-dibromo-alpha-(cyclohexylmethylamino)-o-tolyl]carbamoyl]ethylene]] dicarbamate
CAS No. 86042-50-4
项目整合开发状态: Phase III
项目研究机构: Recordati (Originator)
合成路线:The reaction of cysteine (I) with benzyl chloroformate (II) in the usual way gives the corresponding di(benzyloxycarbonyl) derivative (III),which is treated with PCl5 or SOCl2 in CHCl3 to afford the bisacyl chloride (IV).Finally,this compound is condensed with 4,6-dibromo-2-(cyclohexylmethylaminomethyl) aniline (V) in ethyl acetate.
📌 参考资料/链接：
参考文献标题:Therapeutically effective derivatives of cystine
文献作者:Nardi,D.; Tajana,A.; Motta,G.; Cazzulani,P.; Graziani,G.(Recordati Industria Chimica e Farmaceutica SpA)
参考来源:DE 3225274; EP 0069527; FR 2509298; GB 2102792; JP 58032860; US 4438133
📄 详细内容
合成路线:The reaction of cysteine (I) with benzyl chloroformate (II) in the usual way gives the corresponding di(benzyloxycarbonyl) derivative (III),which is treated with PCl5 or SOCl2 in CHCl3 to afford the bisacyl chloride (IV).Finally,this compound is condensed with 4,6-dibromo-2-(cyclohexylmethylaminomethyl) aniline (V) in ethyl acetate.
参考文献标题:Cistinexine
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1986,11(3),181
合成路线:The reaction of cysteine (I) with benzyl chloroformate (II) in the usual way gives the corresponding di(benzyloxycarbonyl) derivative (III),which is treated with PCl5 or SOCl2 in CHCl3 to afford the bisacyl chloride (IV).Finally,this compound is condensed with 4,6-dibromo-2-(cyclohexylmethylaminomethyl) aniline (V) in ethyl acetate.
参考文献标题:
文献作者:Giannini,E.H.
参考来源:Farm Sci Ed 1985,40(2),108-119
产品链接: CAS No. 86042-50-4››