B-4128
N,5-二(2,4-二氯苯基)-3-(2,2,6,6-四甲基哌啶-4-基亚氨基)-3,5-二氢吩嗪-2-胺Chemical Name: N,5-Bis(2,4-dichlorophenyl)-3-(2,2,6,6-tetramethylpiperidin-4-ylimino)-3,5-dihydrophenazin-2-amine
CAS No. 175096-73-8
项目整合开发状态: Biological Testing
项目研究机构: Adcock Ingram (Originator), University College Dublin (Originator), University of Pretoria (Originator)
合成路线:Hydrogenation of 1-anilino-2-nitrobenzene derivative (I) over Pd/C affords the corresponding diphenylamine (II),which is oxidatively condensed by means of FeCl3 and HCl or AcOH in EtOH to form the iminophenazine derivative (III).Finally,the target compound can be obtained by reaction of (III) with substituted amine (IV) in refluxing dioxane.
📌 参考资料/链接：
参考文献标题:Use of riminophenazines as antimicrobial and antimalarial agents
文献作者:Medlen,C.E.; Anderson,R.; Huygens,F.(University of Pretoria)
参考来源:WO 9745120
📄 详细内容
合成路线:Hydrogenation of 1-anilino-2-nitrobenzene derivative (I) over Pd/C affords the corresponding diphenylamine (II),which is oxidatively condensed by means of FeCl3 and HCl or AcOH in EtOH to form the iminophenazine derivative (III).Finally,the target compound can be obtained by reaction of (III) with substituted amine (IV) in refluxing dioxane.
参考文献标题:Use of riminophenzine for treating MDR resistance
文献作者:Anderson,R.; Medlen,C.E.; O'Sullivan,J.F.(Adcock Ingram Ltd.; University of Pretoria)
参考来源:EP 0676201; US 5763443
产品链接: CAS No. 175096-73-8››