Y-27152

N-(苄氧基)-n-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)乙酰胺Chemical Name: (+)-(3S,4R)-trans-4-(N-Acetyl-N-benzyloxyamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbonitrile; (+)-(3S,4R)-trans-N-(Benzyloxy)-N-(6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)acetamide; (+)-(3S,4R)-4-(N-Acetyl-N-benzyloxyamino)-3-hydroxy-2,2-dimethyl-6-chromancarbonitrile
CAS No. 127408-30-4, 127408-32-6 ((-)-enantiomer)
项目整合开发状态: Phase II
项目研究机构: Mitsubishi Pharma (Originator), Japan Tobacco (Licensee)
合成路线:This compound is prepared as follows:Optical active (-)-epoxide (I) is reacted with O-benzylhydroxylamine (II) to give (+)-trans-4-benzyloxyamino-3-ol (III),which,without further purification,is converted with acetyl chloride/pyridine into the final product,Y-27152.