DAA-1106

N-(2,5-二甲氧基苄基)-N-(5-氟-2-苯氧基苯基)乙酰胺Chemical Name: N-(2,5-Dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide
CAS No. 220551-92-8
项目整合开发状态: Preclinical
项目研究机构: Nihon Nohyaku (Originator), Taisho (Originator)
合成路线:4-Chloro-2-phenoxyaniline (I) was acylated with acetyl chloride and triethylamine to afford acetamide (II).Alkylation of the amide N of (II) by 2-isopropoxybenzyl chloride (III) in the presence of NaH provided the target tertiary amide.

合成路线:5-Fluoro-2-phenoxyaniline (I) was acylated with acetyl chloride and triethylamine to afford acetamide (II).Alkylation of the amide N by 2,5-dimethoxybenzyl chloride (III) in the presence of NaH provided the target tertiary amide.