Bz-423

7-氯-1,3-二氢-5-(4-羟基苯基)-1-甲基-3-(2-萘甲基)-2H-1,4-苯并二氮杂-2-Chemical Name: 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
CAS No. 216691-95-1
项目整合开发状态: Preclinical
项目研究机构: University of California, Berkeley (Originator), University of Michigan (Originator)
合成路线:Acylation of the 2-aminobenzophenone (I) with bromoacetyl bromide (II) provides the bromoacetamide (III).Subsequent treatment of (III) with ammonia leads to the benzodiazepinone (IV).Methylation of the lactam N with iodomethane in the presence of K2CO3 gives rise to (V).The potassium enolate of benzodiazepinone (V) is then alkylated by 2-(bromomethyl)naphthalene (VI) to furnish the naphthylmethyl derivative (VII).Finally,methyl ether cleavage using AlBr3 in ethanethiol provides the target phenolic compound