新产品编号:813657

7-氮杂双环[2.2.1]庚烷,2-(吡啶基)-,(1R,2R,4S)-rel-(9CI)Chemical Name: exo-2-(4-Pyridazinyl)-7-azabicyclo[2.2.1]heptane
CAS No. 324575-73-7
项目整合开发状态: Biological Testing
项目研究机构: Bayer (Originator)
合成路线:The bicyclic ester (I) was reduced to alcohol (II) using LiBH4.Subsequent Swern oxidation of (II) afforded aldehyde (III).Wittig reaction of aldehyde (III) with methoxymethylene triphenylphosphorane gave rise to the enol ether (IV).Diels-Alder reaction of (IV) with tetrazine (V),with concomitant elimination of nitrogen,furnished the pyridiazine (VI).Finally,acid hydrolysis of the carbamate group of (VI) provided the title compound.