STO-609
7-氧代-7H-苯并咪唑并[2,1-a]苯并[de]异喹啉-3-羧酸乙酸盐Chemical Name: 7-Oxo-7H-benzimidazo[2,1-a]benzo[de]isoquinoline-3-carboxylic acid
CAS No. 52029-86-4
项目整合开发状态: Biological Testing
项目研究机构: Sumitomo Pharmaceuticals (Originator)
合成路线:The title compound is prepared starting from the previously reported 3-bromo-1,8-naphthoylenebenzimidazole (I).Cyanation of (I) with cuprous cyanide in pyridine affords nitrile (II).This is then hydrolyzed to the target carboxylic acid employing sulfuric acid in aqueous acetic acid.
📌 参考资料/链接：
参考文献标题:STO-609,a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase
文献作者:Tokumitsu,H.; Inuzuka,H.; Ishikawa,Y.; Ikeda,M.; Saji,I.; Kobayashi,R.
参考来源:J Biol Chem 2002,277(18),15813