OPC-4392
7-[3-[4-(2,3-二甲基苯基)哌嗪基]丙氧基]-2(1H)-喹啉酮Chemical Name: 7-[3-[4-(2,3-Dimethylphenyl)piperazinyl]propoxy]-2(1H)-quinolinone
CAS No. 111073-34-8
项目整合开发状态: Phase III
项目研究机构: Otsuka (Originator)
合成路线:The condensation of 7-hydroxycarbostyryl (I) with 1-bromo-3-chloropropane (II) by means of KOH in hot isopropranol gives 7-(3-chloropropoxy)carbostyryl (III),which is then allowed to react with 1-(2,3-dimethylpheny)piperazine (IV) by means of NaI and NaHCO3 in hot acetone.
📌 参考资料/链接：
参考文献标题:Pharmaceutically useful carbostyril derivs.
文献作者:Banno,K.; Fujioka,T.; Nakagawa,K.; Oshiro,Y.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:DE 2912105; FR 2421174; US 4734416
📄 详细内容
合成路线:The condensation of 7-hydroxycarbostyryl (I) with 1-bromo-3-chloropropane (II) by means of KOH in hot isopropranol gives 7-(3-chloropropoxy)carbostyryl (III),which is then allowed to react with 1-(2,3-dimethylpheny)piperazine (IV) by means of NaI and NaHCO3 in hot acetone.
参考文献标题:OPC-4392
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(10),931
产品链接: CAS No. 111073-34-8››