Caldaret hydrate, MCC-135
5-甲基-2-(1-哌嗪基)-苯磺酸一水合物 5-甲基-2-哌嗪-1-基苯磺酸 Chemical Name: 5-Methyl-2-(1-piperazinyl)benzenesulfonic acid monohydrate
CAS No. 192509-24-3, 133804-44-1 (anhydrous)
项目整合开发状态: Phase II
项目研究机构: Mitsubishi Chemical (Originator), Takeda (Licensee)
合成路线:The title compound was obtained by condensation between 2-fluoro-5-methylbenzenesulfonic acid (I) and piperazine (II) in the presence of copper powder and cuprous iodide in a sealed tube at 160 C.It was converted to the more stable monohydrate form by suspension of the anhydrous crystals in cold water.
📌 参考资料/链接：
参考文献标题:Aminobenzenesulfonic acid deriv.
文献作者:Okushima,H.; Narimatsu,A.; Kobayashi,M.; Satoh,N.; Morita,M.(Mitsubishi Chemical Corp.)
参考来源:EP 0390654; JP 1991007263; US 5053409
📄 详细内容
合成路线:The title compound was obtained by condensation between 2-fluoro-5-methylbenzenesulfonic acid (I) and piperazine (II) in the presence of copper powder and cuprous iodide in a sealed tube at 160 C.It was converted to the more stable monohydrate form by suspension of the anhydrous crystals in cold water.
参考文献标题:Monohydrates of aminobenzenesulfonic acid derivs.and method for preparation thereof
文献作者:Yamazaki,C.; Sato,T.; Nagano,T.(Mitsubishi Chemical Corp.)
参考来源:EP 0779283; JP 2001316381; US 5990113; US 6245767
产品链接: CAS No. 192509-24-3›› 产品链接: CAS No.133804-44-1››