VUF-2274
5-[4-(4-氯苯基)-4-羟基-1-哌啶基]-2,2-二苯基戊腈Chemical Name: 5-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile
CAS No. 193542-65-3
项目整合开发状态: Biological Testing
项目研究机构: Berlex (Originator), Vrije Universiteit (Originator)
合成路线:Diphenylacetonitrile (I) was alkylated with 1,3-dibromopropane (II) in the presence of NaH in DMF to afford the bromopropyl derivative (III).Subsequent condensation of bromide (III) with 4-(4-chlorophenyl)-4-hydroxypiperidine (IV) gave the tertiary amine (V).This was then quaternized with methyl iodide to furnish the corresponding piperidinium salt.
合成路线:Alkylation of diphenylacetonitrile (I) with 1,3-dibromopropane (II) in the presence of NaH in DMF affords 5-bromo-2,2-diphenylvaleronitrile (III).This is then condensed with 4-(4-chlorophenyl)-4-hydroxypiperidine (IV) to produce the title compound.
📌 参考资料/链接：
参考文献标题:Discovery of novel non-peptide CCR1 receptor antagonists
文献作者:Ng,H.P.; May,K.; Bauman,J.G.; Ghannam,A.; Islam,I.; Liang,M.; Horuk,R.; Hesselgesser,J.; Snider,R.M.; Perez,H.D.; Morrissey,M.M.
参考来源:J Med Chem 1999,42(22),4680
📄 详细内容
合成路线:Alkylation of diphenylacetonitrile (I) with 1,3-dibromopropane (II) in the presence of NaH in DMF affords 5-bromo-2,2-diphenylvaleronitrile (III).This is then condensed with 4-(4-chlorophenyl)-4-hydroxypiperidine (IV) to produce the title compound.
参考文献标题:Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor
文献作者:Hesselgesser,J.; Ng,H.P.; Liang,M.; Zheng,W.; May,K.; Bauman,J.G.; Monahan,S.; Islam,I.; Wei,G.P.; Ghannam,A.; Taub,D.D.; Rosser,M.; Snider,R.M.; Morrissey,M.M.; Perez,H.D.; Horuk,R.
参考来源:J Biol Chem 1998,273(25),15687
产品链接: CAS No. 193542-65-3››