NSC-264880, DHAC
5,6-二氢-5-氮杂胞苷 6-氨基-3-((2R,3R,4S,5R)-3,4-二羟基-5-(羟基甲基)四氢呋喃-2-基)-3,4-二氢-1,3,5-三嗪-2 (1H)-酮盐酸盐 Chemical Name: 5,6-Dihydro-5-azacytidine; 4-Amino-1-(beta-D-ribofuranosyl)-1,2,5,6-tetrahydro-1,3,5-triazin-2-one
CAS No. 62488-57-7, 62402-31-7 (monoHCl)
项目整合开发状态: Phase II
项目研究机构: National Cancer Institute (Originator)
合成路线:Borohydride reduction of 5-azacytidine (I) gives 5,6-dihydro-5-azacytidine hydrochloride (II) after acid hydrolysis of a boron-containing intermediate.
📌 参考资料/链接：
参考文献标题:DHAC
文献作者:Pento,J.T.
参考来源:Drugs Fut 1984,9(1),15
📄 详细内容
合成路线:Borohydride reduction of 5-azacytidine (I) gives 5,6-dihydro-5-azacytidine hydrochloride (II) after acid hydrolysis of a boron-containing intermediate.
参考文献标题:Synthesis and antitumor activity of dihydro-5-azacytidine,a hydrolytically stable analogue of 5-zacytidine
文献作者:Beisler,J.A.; Abbasi,M.M.; Kelley,J.A.; Driscoll,J.S.
参考来源:J Med Chem 1977,20(6),806-812
产品链接: CAS No. 62488-57-7›› 产品链接: CAS No.62402-31-7››