新产品编号:914905

5,6-二氢-5-氧代吲哚并[1,2-a]喹唑啉-7-乙酸Chemical Name: 2-(5-Oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid
CAS No. 391670-48-7
项目整合开发状态: Biological Testing
项目研究机构: Novartis (Originator)
合成路线:The dibenzoazepine-5-carbonitrile (I) is converted to its 11-cyano isomer (II) in the presence of potassium tert-butoxide in dichloroethane.Alkylation of the keto nitrile (II) with ethyl bromoacetate leads to the dibenzoazepine derivative (III).Rearrangement of (III) under basic conditions affords the indoloquinazoline (IV).Finally,alkaline hydrolysis of methyl ester (IV) provides the corresponding carboxylic acid.