RS-04, RS-481, RS-0481
4-硫唑胺羧酰胺,3-苯甲酰-N-(1-苯乙基)-Chemical Name: (4R)-3-Benzoyl-N-[(1R)-1-phenylethyl]-4-thiazolidinecarboxamide
CAS No. 104682-67-9 (undefined stereoch.)
项目整合开发状态: Phase I
项目研究机构: Sankyo (Originator)
合成路线:The benzoylation of thiazolidine-4(R)-carboxylic acid (I) with benzoyl chloride (II) by means of NaOH in acetone water gives the corresponding N-benzoyl derivative (III),which is then condensed with alpha-(R)-methylbenzylamine (IV) by means of isobutyl chloroformate and triethylamine in dichloromethane.
📌 参考资料/链接：
参考文献标题:RS-0481
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1988,13(7),627
📄 详细内容
合成路线:The benzoylation of thiazolidine-4(R)-carboxylic acid (I) with benzoyl chloride (II) by means of NaOH in acetone water gives the corresponding N-benzoyl derivative (III),which is then condensed with alpha-(R)-methylbenzylamine (IV) by means of isobutyl chloroformate and triethylamine in dichloromethane.
参考文献标题:Amino acid derivatives having anti-tumor activity and compositions containing them.
文献作者:Matsui,T.; Nagano,M.; KLitamura,K.; Shimizu,F.(Sankyo Co.,Ltd.)
参考来源:EP 0173441; ES 8703830; US 4904680
产品链接: CAS No. 104682-67-9››