合成路线:4-Nitrobenzoyl chloride (I) was condensed with tert-butyl amine to give amide (II).The nitro group of (II) was then reduced to aniline (III) by transfer hydrogenation with hydrazine and Pd/C.Finally,acylation of (III) with acetyl chloride provided the title acetamide.
参考文献标题:Benzamide therapeutics for the treatment of inflammatory bowel disease
文献作者:Flitter,W.D.; Irwin,I.; Garland,W.A.(Centaur Pharmaceuticals,Inc.)
参考来源:WO 9959569
合成路线:4-Nitrobenzoyl chloride (I) was condensed with tert-butyl amine to give amide (II).The nitro group of (II) was then reduced to aniline (III) by transfer hydrogenation with hydrazine and Pd/C.Finally,acylation of (III) with acetyl chloride provided the title acetamide.
参考文献标题:Benzamide treatment of dementia,associated with AIDS virus (HIV-1) infection
文献作者:Garland,W.(Centaur Pharmaceuticals,Inc.)
参考来源:WO 9738684
合成路线:4-Nitrobenzoyl chloride (I) was condensed with tert-butyl amine to give amide (II).The nitro group of (II) was then reduced to aniline (III) by transfer hydrogenation with hydrazine and Pd/C.Finally,acylation of (III) with acetyl chloride provided the title acetamide.
参考文献标题:CPI-1189
文献作者:Sorbera,L.A.; Castar,J.; Leeson,P.A.
参考来源:Drugs Fut 2001,26(7),647
产品链接: CAS No. 183619-38-7››