MEN-11066
4-{[2-(1-苯呋喃-2-基)-2,3-二氢-1H-1,2,4-三唑-1-基]甲基}苯并腈Chemical Name: (?-4-[1-(Benzofuran-2-yl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile
CAS No. 207288-29-7
项目整合开发状态: Preclinical
项目研究机构: Menarini (Originator)
合成路线:Methanol derivative (I) is converted into the corresponding methyl chloride compound (II) by reaction with thionyl chloride in dichloromethane/cyclohexane.The desired product is then obtained by displacement of the chlorine by attack with 1H-1,2,4-triazole (III) in dioxane.
📌 参考资料/链接：
参考文献标题:New (benzofuran-2-yl)imidazoles having pharmaceutically activity,their salts and relevant production processes
文献作者:Pestellini,V.; Ghelardoni,M.; Giannotti,D.; Giolitti,A.; Barzanti,A.; Ciappi,R.; Ortolani,C.(Menarini Industrie Farma Riunite Srl)
参考来源:EP 0257171; JP 1988072687; US 4800208
📄 详细内容
合成路线:Methanol derivative (I) is converted into the corresponding methyl chloride compound (II) by reaction with thionyl chloride in dichloromethane/cyclohexane.The desired product is then obtained by displacement of the chlorine by attack with 1H-1,2,4-triazole (III) in dioxane.
参考文献标题:Heterocyclic furan cpds.,their preparation and use as aromatase inhibitors
文献作者:Lombardi,P.; Di Pietro,G.(Menarini Industrie Farma Riunite Srl)
参考来源:WO 9818791
产品链接: CAS No. 207288-29-7››