TetramethylHES
4-[3-(4-羟基苯基)-2,3-二甲基丁烷-2-基]苯酚Chemical Name: 1,1,2,2-Tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane; 2,3-Dimethyl-2,3-bis(4'-hydroxyphenyl)butane; 4,4'-(1,1,2,2-Tetramethylethylene)diphenol
CAS No. 74385-27-6
项目整合开发状态: Biological Testing
项目研究机构: Universit鋞 Regensburg (Originator)
合成路线:The tertiary alcohol (I) can be obtained by Grignard reaction of methyl 4-methoxybenzoate with methylmagnesium iodide.The bibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3 - LiAlH4,according to the method of McMurry and Silvestri.The cleavage of the methoxy groups is performed with BBr3 and gives tetramethylHES.
📌 参考资料/链接：
参考文献标题:Tetramethylhes
文献作者:Hartmann,R.W.
参考来源:Drugs Fut 1985,10(1),48
📄 详细内容
合成路线:The tertiary alcohol (I) can be obtained by Grignard reaction of methyl 4-methoxybenzoate with methylmagnesium iodide.The bibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3 - LiAlH4,according to the method of McMurry and Silvestri.The cleavage of the methoxy groups is performed with BBr3 and gives tetramethylHES.
合成路线:The synthesis of D-18954 is performed using dimethyl(2-fluoro-4-methoxy-phenyl)carbinol (I) as educt.The tertiary alcohol (I) can be obtained by Grignard reaction of 2-fluoro-4-methoxyacetophenone with methyl magnesium iodide.The dibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3-LiAlH4,according to the method of McMurry and Silvestri.The cleavage of the methoxy groups is accomplished with BBr3 and gives D-18954.
参考文献标题:Simplified method for the titanium (II)-induced coupling of allylic and benzylic alcohols
文献作者:Silvestri,M.A.; McMurry,J.E.
参考来源:J Org Chem 1975,402687
合成路线:The tertiary alcohol (I) can be obtained by Grignard reaction of methyl 4-methoxybenzoate with methylmagnesium iodide.The bibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3 - LiAlH4,according to the method of McMurry and Silvestri.The cleavage of the methoxy groups is performed with BBr3 and gives tetramethylHES.
参考文献标题:Antiestrogens.Synthesis and evaluation of mammary tumor inhibiting activity of 1,1,2,2-tetraalkyl-1,2-diphenylethanes
文献作者:Hartmann,R.W.; Kranzfelder,G.; Angerer,E.; Sch鰊enberger,H.
参考来源:J Med Chem 1980,23(8),841-844
产品链接: CAS No. 74385-27-6››