KF-4317
4-[2-羟基-3-[(1-甲基-3-苯丙基)氨基]丙氧,苯乙酰胺Chemical Name: 4-[2-Hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propoxy]benzeneacetamide; 4-[2-Hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propoxy]phenylacetamide; 1-[4-(Carbamoylmethyl)phenoxy]-3-(1-methyl-3-phenylpropylamino)-2-propanol
CAS No. 76805-48-6
项目整合开发状态: Biological Testing
项目研究机构: Kyowa Hakko (Originator)
合成路线:The addition of N-benzyl-3-phenyl-1-methylpropylamine (I) to ethyl 4-(2,3-oxidopropoxy)phenylacetate (II) in refluxing ethanol,followed by debenzylation with H2 over Pd/C gives 1-[4-(ethoxycarbonylmethyl)phenoxyl-3-(1-methyl-3-phenylpropylamino)-2-propanol (III),which is then treated with NH3 in ethanol.
📌 参考资料/链接：
参考文献标题:Amino-alcohol derivatives
文献作者:Takizawa,H.; Oiji,Y.; Kubo,K.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:DE 3010752; US 4381398
📄 详细内容
合成路线:The addition of N-benzyl-3-phenyl-1-methylpropylamine (I) to ethyl 4-(2,3-oxidopropoxy)phenylacetate (II) in refluxing ethanol,followed by debenzylation with H2 over Pd/C gives 1-[4-(ethoxycarbonylmethyl)phenoxyl-3-(1-methyl-3-phenylpropylamino)-2-propanol (III),which is then treated with NH3 in ethanol.
参考文献标题:KF-4317
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1984,9(3),189
产品链接: CAS No. 76805-48-6››